The R621 is a Regional Route in South Africa.[1]
| Country: | ZAF |
| Type: | R |
| Route: | 621 |
| Previous Type: | R |
| Previous Route: | 620 |
| Next Type: | R |
| Next Route: | 622 |
Its north-western terminus is the N11 between Ladysmith and Newcastle. It initially heads east, to Dannhauser. Leaving the town, it heads south-east, and passes through Hattingspruit before ending at an intersection with the R68 just north of Dundee.