| Country: | CZE |
| Type: | D |
| Route: | 46 |
| Map: | Motorway D46-CZ map.svg |
| Length Km: | 37 |
| Terminus A: | near Vyškov |
| Junction: | near Olomouc |
| Terminus B: | Olomouc |
| Regions: | South Moravia, Olomouc |
| Cities: | Vyškov, Prostějov, Olomouc |
D46 motorway (Czech: Dálnice D46), formerly Expressway R46 (Czech: Rychlostní silnice R46) is a highway in southern Czech Republic. It was built from 1974 to 1992. Currently, as the D1 highway is not finished yet, it carries all international traffic, but after completion of it, it will have only regional traffic in central Moravia.