| Country: | ZAF |
| Route: | 405 |
| Type: | R |
| Next Type: | R |
| Previous Type: | R |
| Previous Route: | 404 |
| Next Route: | 406 |
The R405 is a Regional Route in South Africa. Its southern terminus is the N2 at Mount Frere in the Eastern Cape. It runs north-west to meet the R56 midway between Mount Fletcher and Matatiele.