The R380 is a Regional Route in South Africa that connects Kathu with the Botswana border at McCarthy's Rest via Hotazel.[1]
| Country: | ZAF |
| Route: | 380 |
| Type: | R |
| Next Type: | R |
| Previous Type: | R |
| Previous Route: | 378 |
| Next Route: | 381 |
From the border, it heads generally south-south-east to Hotazel. Here it crosses the R31 at a staggered junction (co-signed for 16 kilometres). It then heads south, by-passing Dibeng to the east, before veering south-east to reach its southern terminus at a junction with the N14 at Kathu.