| Country: | ZAF |
| Type: | R |
| Route: | 353 |
| Length Round: | 0 |
| Direction A: | North |
| Terminus A: | Brandvlei |
| Direction B: | South |
| Terminus B: | Leeu-Gamka |
| Towns: | Fraserburg, Williston |
| Previous Type: | R |
| Previous Route: | 352 |
| Next Type: | R |
| Next Route: | 354 |
The R353 is a Regional Route in South Africa that connects Leeu-Gamka with Brandvlei via Fraserburg and Williston.
Its north-eastern terminus is the R357 at Brandvlei, Northern Cape. It initially heads south, then south-east to Williston where it meets the R63. It crosses at a staggered junction, and continues south-east to Fraserburg. At Fraserburg it crosses the R356 at another staggered junction. From Fraserburg it heads south-south-east. It passes through the Nuweveld Mountains via the Teekloof Pass and then enters the Western Cape. The route ends at Leeu-Gamka at the N1.[1]