| Country: | RUS |
| Type: | R |
| Route: | 255 |
| Alternate Name: | Novosibirsk–Irkutsk Highway |
| Map: | M53 karte RF.jpg |
| Length Km: | 1860 |
| Direction A: | West |
| Terminus A: | in Novosibirsk |
| Direction B: | East |
| Terminus B: | in Irkutsk |
| Previous Type: | R |
| Previous Route: | 254 |
| Next Type: | R |
| Next Route: | 256 |
The Russian route R255 is a federal highway in Russia, part of the Trans-Siberian Highway: [1] Novosibirsk-(Tomsk-)Kemerovo-Krasnoyarsk-Tayshet-Irkutsk, 1860 km.
Before 2018, the road was designated as M53.