| Río Segundo Department | |
| Native Name: | Departamento Río Segundo |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | frameless |
| Coordinates: | -31.7567°N -63.61°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Established Title: | Foundation |
| Seat Type: | Capital |
| Seat: | Villa del Rosario |
| Unit Pref: | Metric |
| Area Total Km2: | 4970 |
| Population Total: | 95803 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Pop. change |
| Population Blank1: | +13.52% |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | Postal code |
| Postal Code: | X5963 |
| Area Code Type: | Dialing code |
| Area Code: | 0357 |
| Blank Name Sec1: | Distances to |
| Blank Info Sec1: | |
| Blank1 Info Sec1: | 648km (403miles) |
| Blank2 Name Sec1: | Córdoba |
| Blank2 Info Sec1: | 75km (47miles) |
Río Segundo Department is a department of Córdoba Province in Argentina.
The provincial subdivision has a population in 2001 of 95,803 in an area of . Its capital city is Villa del Rosario, which is located from the Buenos Aires.