| Santiago River | |
| Subdivision Type1: | Commonwealth |
| Subdivision Name1: | Puerto Rico |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Naguabo |
| Length: | 5.95 miles |
| Basin Size: | 6.84 sq miles |
Río Santiago is a short river of Puerto Rico. About long, it is spanned by historic Bridge No. 122 on the coastal road near barrio Duque in Naguabo, Puerto Rico. It discharges into the Caribbean Sea from Naguabo.[1]