| Río Grande de Lipez | |
| Subdivision Type1: | Country |
| Subdivision Name1: | Bolivia |
| Subdivision Type3: | Region |
| Subdivision Name3: | Potosí Department |
| Length: | 153km (95miles) |
| Source1 Coordinates: | -21.6736°N -67.0481°W |
| Mouth: | Uyuni salt flat |
| Mouth Coordinates: | -20.6456°N -67.2917°W |
The Río Grande de Lípez is a river of Bolivia in the Potosí Department, Nor Lípez Province.