Quinpirole Explained

Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist. It is used in scientific research.[1] [2] [3] Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic of obsessive compulsive disorder in rats.[4] Another study in rats show that quinpirole produces significant THC-like effects when metabolic degradation of anandamide is inhibited, supporting the hypothesis that these effects of quinpirole are mediated by cannabinoid CB1 receptors.[5] Quinpirole may also reduce relapse in adolescent rat models of cocaine addiction.[6]

Experiments in flies found quinpirole may have neuroprotective effects against Parkinson's disease-like pathology.[7] Moreover, in primary neuronal cultures it also reduces the rate of firing in dopaminergic neurons.

See also

Notes and References

  1. Eilam D, Szechtman H . Biphasic effect of D-2 agonist quinpirole on locomotion and movements . European Journal of Pharmacology . 161 . 2–3 . 151–7 . February 1989 . 2566488 . 10.1016/0014-2999(89)90837-6.
  2. Navarro JF, Maldonado E . Behavioral profile of quinpirole in agonistic encounters between male mice . Methods and Findings in Experimental and Clinical Pharmacology . 21 . 7 . 477–80 . September 1999 . 10.1358/mf.1999.21.7.550110 . 10544391 . 25978291 .
  3. Culm KE, Lugo-Escobar N, Hope BT, Hammer RP . Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats . Neuropsychopharmacology . 29 . 10 . 1823–30 . October 2004 . 15138441 . 10.1038/sj.npp.1300483 . free .
  4. 10.1037/0735-7044.112.6.1475. Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD). 1998. Szechtman. Henry. Sulis. William. Eilam. David. Behavioral Neuroscience. 112. 6. 1475–85. 9926830. 11375/26795. free.
  5. Solinas. Marcello. Tanda. Gianluigi. Wertheim. Carrie E.. Goldberg. Steven R.. 2016-10-08. Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide. 2834964. Psychopharmacology. 209. 2. 191–202. 10.1007/s00213-010-1789-8. 0033-3158. 20179908.
  6. Zbukvic. Isabel C.. Ganella. Despina E.. Perry. Christina J.. Madsen. Heather B.. Bye. Christopher R.. Lawrence. Andrew J.. Kim. Jee Hyun. 2016-06-01. Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats. Cerebral Cortex. en. 26. 6. 2895–2904. 10.1093/cercor/bhw051. 26946126. 1047-3211. 4869820.
  7. Wiemerslage L, Schultz BJ, Ganguly A, Lee D . Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture. . J Neurochem . 126 . 4 . 529–40 . 2013 . 23452092 . 10.1111/jnc.12228 . 3737274.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Quinpirole".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.