Quinalizarin Explained

Quinalizarin or 1,2,5,8-tetrahydroxyanthraquinone is an organic compound with formula . It is one of many tetrahydroxyanthraquinone isomers, formally derived from anthraquinone by replacement of four hydrogen atoms by hydroxyl (OH) groups at the 1, 2, 5, and 8 positions.

Quinalizarin is an inhibitor of the enzyme protein kinase CK2. It is more potent and selective than emodin.^[1] It is also a potent catechol O-methyltransferase (COMT) inhibitor.^{[2] [3]}

See also

• 1,4-Dihydroxyanthraquinone (quinizarin)
• Alizarin, a related simpler dye

Notes and References

1. Cozza, G. . Mazzorana, M. . Papinutto, E. . Bain, J. . Elliott, M. . di Maira, G. . Gianoncelli, A. . Pagano, M. A. . Sarno, S. . Ruzzene, M. . Battistutta, R. . Meggio, F. . Moro, S. . Zagotto, G. . Pinna, L. A. . Quinalizarin as a Potent, Selective and Cell-Permeable Inhibitor of Protein Kinase CK2 . The Biochemical Journal . 2009 . 421 . 3 . 387–395 . 10.1042/BJ20090069 . 19432557 .
2. Schneider J, Huh MM, Bradlow HL, Fishman J . Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells . J. Biol. Chem. . 259 . 8 . 4840–5 . April 1984 . 6325410 .
3. Schütze N, Vollmer G, Knuppen R . Catecholestrogens are agonists of estrogen receptor dependent gene expression in MCF-7 cells . J. Steroid Biochem. Mol. Biol. . 48 . 5-6 . 453–61 . April 1994 . 8180106 . 10.1016/0960-0760(94)90193-7 .