| Quepe River | |
| Map: | Txu-oclc-224571178-sj18-12.jpg |
| Map Alt: | Quepe River, few kilometers South of Temuco |
| Source1 Location: | Laguna Quepe |
| Subdivision Type1: | Country |
| Subdivision Name1: | Chile |
| Length: | 112km (70miles)[1] |
| Pushpin Map: | Chile |
Quepe River is a river of Chile located in the La Araucanía Region. It originates in the lake of the same name, in the vicinity of Llaima volcano. Then flows about 112 km to join the Cautín River near the locality of Almagro, only a few kilometres upstream of the confluence of the rivers Cautín and Chol Chol, point of origin of the Imperial River.