Quentin Gibson Explained

Professor Quentin Gibson
Birth Name:Quentin Howieson Gibson
Birth Date:1918 12, df=yes
Birth Place:Aberdeen, Scotland
Spouse:Audrey Jane Pinsent
Children:4
Citizenship:British, American
Education:Queen's University Belfast
Fields:Biochemistry of heme proteins
Workplaces:University of Sheffield
Cornell University
University of Pennsylvania
Notable Students:Keith Moffat[1]
Awards:Fellow of the Royal Society (1969)[2]

Quentin Howieson Gibson FRS[2] (9 December 1918 – 16 March 2011) was a Scottish American physiologist, and professor at the University of Sheffield,[3] and Cornell University.[4]

Education

Gibson earned a Doctor of Medicine degree in 1944 and a Ph.D. in 1946, from Queen's University Belfast.

Life

Gibson taught at the University of Sheffield from 1947. Whilst at the University of Sheffield Gibson met Audrey Jane Pinsent in 1951. They married, started a family, and eventually had four children. Jane Gibson continued working part-time whilst raising her family. In 1963 they emigrated to the United States, where she took up positions, first at the University of Pennsylvania.[5] He succeeded (Sir) Hans Krebs as the Head of the Department of Biochemistry in 1955. In 1963 he left Sheffield to become a professor at the University of Pennsylvania. He was the Greater Philadelphia Professor at Cornell University, from 1965 to 1996.In 1982, he became a U.S. citizen.[6]

Research

Hemoglobin

Gibson started his career with studies of hemoglobin,[7] [8] and continued with much other work on heme proteins.

Medical and physiological work

In keeping with his medical qualifications, much of Gibson's early work[9] [10] had medical or physiological relevance.[11]

Cooperativity

During the period when protein and enzyme cooperativity was at the center of biochemical interest Gibson studied it in the context of abnormal hemoglobins.[12] [13]

Rapid reactions

Gibson made major contributions to the development of methods for studying rapid reactions,[14] and their application to hemoglobin.[15]

Other proteins

Other work concerned enzymes such as "diaphorase",[16] [17] glucose oxidase,[18] cytochrome oxidase[19] [20] and peroxidase.[21]

Thermodynamics

Much of Gibson's work concerned questions of thermodynamics and equilibria, and in that context he participated in discussions about how to present thermodynamic data.[22]

Awards and honours

Gibson was elected a Fellow of the Royal Society in 1969.[2] He was also a member of the National Academy of Sciences, and an associate editor of the Journal of Biological Chemistry from 1975 to 1994.[23]

External links

Notes and References

  1. Web site: Quentin H. Gibson's Profile on Academic Tree.
  2. Olson . J. S. . Gutfreund . H. . Quentin Howieson Gibson 9 December 1918 -- 16 March 2011 . 10.1098/rsbm.2013.0018 . . 2013 . 60 . 169–210 .
  3. Web site: Quentin H. Gibson . Cf.ac.uk . 2011-12-21.
  4. Web site: Notices 2011 . Royal Society . 2011-12-21.
  5. Web site: Bretscher. Anthony. Audrey Jane Gibson. ecommons.cornell.edu. Cornell University. 27 March 2017.
  6. Web site: Olson . John . Retrospective: Quentin H. Gibson . Asbmb.org . 2011-12-21.
  7. 10.1042/bj0370615. The reduction of methaemoglobin by ascorbic acid. 1943. Gibson. Q. H.. Biochemical Journal. 37. 5. 615–618. 16747706. 1257979.
  8. 10.1042/bj0420013. The reduction of methaemoglobin in red blood cells and studies on the cause of idiopathic methaemoglobinaemia. 1948. Gibson. Q. H.. Biochemical Journal. 42. 1. 13–23. 16748235. 1258588.
  9. 10.1136/bmj.1.4648.275. Case of Acute Porphyria. 1950. Gibson. Q. H.. Harrison. D. C.. Montgomery. D. A. D.. BMJ. 1. 4648. 275–277. 15410128. 2036737.
  10. 10.1042/bj0480426. Selective absorption of stereo-isomers of amino-acids from loops of the small intestine of the rat. 1951. Gibson. Q. H.. Wiseman. G.. Biochemical Journal. 48. 4. 426–429. 14838861. 1275345.
  11. 10.1086/physzool.60.1.30158635. Blood Flow in the Muscle of Free-Swimming Fish. 1987. Carey. Francis G.. Gibson. Quentin H.. Physiological Zoology. 60. 138–148. 87448894.
  12. 10.1016/0022-2836(75)90382-4. Conformation, co-operativity and ligand binding in human hemoglobin. 1975. Cassoly. Robert. Gibson. Quentin H.. Journal of Molecular Biology. 91. 3. 301–313. 171411.
  13. 10.1113/jphysiol.1957.sp005777. The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin. 1957. Gibson. Q. H.. Roughton. F. J. W.. The Journal of Physiology. 136. 3. 507–526. 13429517. 1358871.
  14. 10.1042/bj0910161. Apparatus for rapid and sensitive spectrophotometry. 1964. Gibson. QH. Milnes. L.. Biochemical Journal. 91. 1. 161–171. 5833381. 1202828.
  15. 10.1042/bj0710293. The photochemical formation of a quickly reacting form of haemoglobin. 1959. Gibson. Q. H.. Biochemical Journal. 71. 2. 293–303. 13628568. 1196788.
  16. 10.1042/bj0770341. Intermediates in the catalytic action of lipoyl dehydrogenase (Diaphorase). 1960. Massey. V.. Gibson. Q. H.. Veeger. C.. Biochemical Journal. 77. 2. 341–351. 13767908. 1204990.
  17. 10.1039/df9541700137. Stopped-flow apparatus for the study of rapid reactions. 1954. Gibson. Q. H.. Discussions of the Faraday Society. 17. 137.
  18. Kinetics and mechanism of action of glucose oxidase . Gibson . Q H . Massey . V . Swoboda . B E P J . J. Biol. Chem. . 239 . 11 . 1964. 3927–3934 . 10.1016/S0021-9258(18)91224-X . 14257628. free .
  19. Reaction of cytochrome oxidase with cytochrome C . Gibson . Q H . Greenwood . C . Wharton . D C . Palmer . G . J. Biol. Chem. . 240 . 2 . 888–894 . 1965 . 10.1016/S0021-9258(17)45258-6 . 14275150 . free .
  20. 10.1002/j.1460-2075.1983.tb01695.x. Oxygen activation by cytochrome oxidase: A new spectral intermediate observed by flow-flash. 1983. Brunori. M.. Gibson. Q.H.. The EMBO Journal. 2. 11. 2025–2026. 6315412. 555404.
  21. Reaction of ferrous horseradish peroxidase with hydrogen peroxide . Noble . R W . Gibson . Q H . J. Biol. Chem. . 245 . 9 . 2409–2413 . 1970. 10.1016/S0021-9258(18)63167-9 . 5442280 . free .
  22. 10.1351/pac199466081641. Recommendations for nomenclature and tables in biochemical thermodynamics (IUPAC Recommendations 1994). 1994. Alberty. Robert A.. Pure and Applied Chemistry. 66. 8. 1641–1666. 96307963. free.
  23. Web site: Volume 250 Issue 24 pages 9215-9438 (J. Biol. Chem.) . 14 April 2021 . 1975.

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