Queen bee acid explained

Queen bee acid (10-hydroxy-2-decenoic acid or 10-HDA) is a fatty acid found in royal jelly.^{[1] [2] [3]}

Queen bee acid is being investigated for its potential pharmacological activities. It promotes neurogenesis of neural stem/progenitor cells (cells capable of differentiating into neurons, astrocytes, or oligodendrocytes) in vitro.^[4] In addition, queen bee acid has been reported to have in vitro anti-tumor, anti-biotic, immunomodulatory, estrogenic, neurogenic, and innate immune response modulating activities.^[5]

In the United States, the Food and Drug Administration has taken legal action against companies that have used unfounded claims of health benefits to market royal jelly products.^{[6] [7]}

See also

• 10-Hydroxydecanoic acid
• 2-Decenedioic acid

External links

• Royal Jelly Uses, Side Effects & Warnings, medically reviewed by Drugs.com on Sep 29, 2020. Written by Cerner Multum.
• 2781774 . 2007 . Izuta . H. . Chikaraishi . Y. . Shimazawa . M. . Mishima . S. . Hara . H. . 10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells . Evidence-Based Complementary and Alternative Medicine . 6 . 4 . 489–494 . 10.1093/ecam/nem152 . 18955252 .

Notes and References

1. Ji. N. Yu, RG . Yang, QH . Yu, PH . Li, Y . [Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography].. Zhong Yao Tong Bao . Jul 1987. 12. 9. 28–31, 62. 3449246.
2. Bloodworth. BC. Harn, CS . Hock, CT . Boon, YO . Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly.. Journal of AOAC International. Jul–Aug 1995. 78. 4. 1019–23. 7580313. 10.1093/jaoac/78.4.1019.
3. Genç. Mahmut. Aslan, Abdurrahman . Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography. Journal of Chromatography A. 839. 1–2. 265–268. 10.1016/S0021-9673(99)00151-X. 10327631. 1999.
4. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomedical Research. 2007-01-01. 261–266. 28. 5. 10.2220/biomedres.28.261. 18000339. Noriko. Hattori. Hiroshi. Nomoto. Hidefumi. Fukumitsu. Satoshi. Mishima. Shoei. Furukawa. free.
5. Royal Jelly Acid, 10-Hydroxy-trans-2-Decenoic Acid, as a Modulator of the Innate Immune Responses. 2012. 10.2174/187153012803832530. Sugiyama. Tsuyoshi. Takahashi. Keita. Mori. Hiroshi. Endocrine, Metabolic & Immune Disorders Drug Targets. 12. 4. 368–376. 23061418.
6. Web site: Federal Government Seizes Dozens of Misbranded Drug Products: FDA warned company about making medical claims for bee-derived products . Apr 5, 2010 . Food and Drug Administration.
7. Web site: Inspections, Compliance, Enforcement, and Criminal Investigations: Beehive Botanicals, Inc . March 2, 2007 . Food and Drug Administration.