| Box Width: | 30em |
| Queen and Crescent Limited | |
| Type: | Inter-city rail |
| First: | 1926 |
| Last: | 1949 |
| Formeroperator: | Southern Railway |
| Start: | Cincinnati, Ohio |
| End: | New Orleans, Louisiana |
| Trainnumber: | 43 and 44 |
The Queen and Crescent Limited was a named passenger train operated by the Southern Railway in the United States of America. It was operated over a historic route that had been established in the late 1800s called the Queen and Crescent Route, which referred to Cincinnati as the "Queen City" and New Orleans as the "Crescent City".
The train began service in 1926 and it was never a financial success. The Southern Railway operated the Queen and Crescent Limited from Cincinnati, Ohio to New Orleans, Louisiana via Lexington, Kentucky, Chattanooga, Tennessee, Birmingham, Alabama and Meridian, Mississippi. The new train carried both coaches and Pullman sleepers and a dining car. Its road numbers on the Southern Railway were #43 (southbound) and #44 (northbound).
The Queen and Crescent was removed from the timetable by 1949 and only a remnant remained: Southern operated Train numbers 43 and 44 between Birmingham, Alabama and Meridian, Mississippi as a local.