| Province: | QC |
| Type: | QC |
| Route: | 397 |
| Maint: | Transports Québec |
| Map: | Route 397-QC.png |
| Length Km: | 130 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction B: | North |
| Direction A: | South |
| Terminus B: | in Lac-Despinassy |
| Terminus A: | in Val-d'Or |
| Previous Type: | QC |
| Previous Route: | 395 |
| Next Type: | QC |
| Next Route: | 399 |
| Cities: | Val-d'Or, Barraute |
Route 397 is a two-lane north/south highway located in the Abitibi-Témiscamingue region in Quebec, Canada. It starts at the junction of Route 117 in Val-d'Or and ends at the junction of Route 113 in Lac-Despinassy. It is also concurrent with Route 386 in Barraute.