| Province: | QC |
| Type: | QC |
| Route: | 395 |
| Maint: | Transports Québec |
| Map: | Route 395-QC.png |
| Length Km: | 109 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction B: | North |
| Direction A: | South |
| Terminus B: | in La Morandière-Rochebaucourt |
| Terminus A: | in Rouyn-Noranda |
| Previous Type: | QC |
| Previous Route: | 393 |
| Next Type: | QC |
| Next Route: | 397 |
| Cities: | Amos, Rouyn-Noranda |
| Junction: | in Amos |
Route 395 is a two-lane north/south highway located in the Abitibi-Témiscamingue region in Quebec, Canada. It starts at the junction of Route 117 in Cadillac (now part of Rouyn-Noranda) and ends at the junction of Route 397 in La Morandière-Rochebaucourt. It is briefly concurrent with Route 111 in Amos.