| Province: | QC |
| Type: | QC |
| Route: | 391 |
| Maint: | Transports Québec |
| Map: | Route 391-QC.png |
| Length Km: | 90 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction A: | South |
| Direction B: | North |
| Terminus B: | in Rouyn-Noranda |
| Terminus A: | north of Saint-Edouard-de-Fabre |
| Previous Type: | QC |
| Previous Route: | 390 |
| Next Type: | QC |
| Next Route: | 393 |
| Cities: | Rouyn-Noranda |
Route 391 is a provincial highway located in the Abitibi-Témiscamingue region in southwestern Quebec near the Ontario border. The 90km (60miles) road runs from the junction of Route 101 near St-Édouard-de-Fabre and ends in Rouyn-Noranda at the junction of Route 117. Between Lorrainville and Laverlochère-Angliers, it overlaps Route 382. Near Rollet, it is also concurrent with Route 101.