| Province: | QC |
| Type: | QC |
| Route: | 388 |
| Maint: | Transports Québec |
| Map: | Route 388-QC.png |
| Length Km: | 25 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | at the Quebec–Ontario border |
| Terminus B: | near Duparquet |
| Previous Type: | QC |
| Previous Route: | 386 |
| Next Type: | QC |
| Next Route: | 389 |
Route 388 is a short provincial highway in the Abitibi-Témiscamingue region of the Canadian province of Quebec.
Approximately 25 kilometres long, the highway is located in the Abitibi-Ouest MRC. It is essentially a continuation of Highway 101 in Ontario, extending from the provincial border to Route 393 just outside Duparquet.