| Province: | QC |
| Type: | QC |
| Route: | 281 |
| Map: | Route 281-QC.png |
| Length Km: | 75 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction A: | North |
| Direction B: | South |
| Terminus A: | near Saint-Michel-de-Bellechasse |
| Terminus B: | in Saint-Camille-de-Lellis |
| Previous Type: | QC |
| Previous Route: | 279 |
| Next Type: | QC |
| Next Route: | 283 |
| Cities: | Saint-Michel-de-Bellechasse Saint-Camille-de-Lellis Saint-Magloire Saint-Philémon Armagh Saint-Raphaël La Durantaye |
| Junction: | near La Durantaye |
Route 281 is a 75 km two-lane north/south highway in the Chaudière-Appalaches region in the province of Quebec, Canada. Its northern terminus is in St-Michel at the junction of Route 132 and its southern terminus is close to Saint-Camille-de-Lellis at the junction of Route 204.