| Province: | QC |
| Type: | QC |
| Route: | 253 |
| Maint: | Transports Québec |
| Map: | Route 253-QC.png |
| Length Km: | 62.4 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction A: | South |
| Direction B: | North |
| Terminus B: | in East Angus |
| Previous Type: | QC |
| Previous Route: | 251 |
| Next Type: | QC |
| Next Route: | 255 |
| Terminus A: | at Canaan, Vermont |
| Counties: | Coaticook / Le Haut-Saint-François |
| Junction: | in Saint-Malo in Cookshire-Eaton |
Route 253 is a north–south highway on the south shore of the St. Lawrence River. Its northern terminus is in East Angus at Route 112 and its southern terminus is at the Vermont border, where it becomes Vermont Route 253.