| Province: | QC |
| Type: | QC |
| Route: | 222 |
| Maint: | Transports Québec |
| Map: | Route 222-QC.png |
| Length Km: | 62.5 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in Roxton Falls |
| Terminus B: | in Sherbrooke |
| Previous Type: | QC |
| Previous Route: | 221 |
| Next Type: | QC |
| Next Route: | 223 |
| Junction: | in Racine in Saint-Denis-de-Brompton in Bromptonville |
Route 222 is a provincial highway located in the Estrie region of Quebec, Canada. The 61km (38miles) highway runs from the junction of Route 139 in Roxton Falls and ends at the junction of Route 143 in Sherbrooke just east of Autoroute 55. It also has a brief concurrency with Route 243 in Racine.