| Province: | QC |
| Type: | QC |
| Route: | 101 |
| Maint: | Transports Québec |
| Map: | Route 101-QC.png |
| Length Km: | 289.3 |
| Length Ref: | [1] |
| Length Round: | 1 |
| Direction A: | South |
| Terminus A: | in Thorne, Ontario |
| Junction: | in Rouyn-Noranda |
| Direction B: | North |
| Terminus B: | in Macamic |
| Counties: | Témiscamingue / Rouyn-Noranda / Abitibi-Ouest |
| Previous Type: | A |
| Previous Route: | 85 |
| Next Type: | QC |
| Next Route: | 104 |
Route 101 is a north-south highway in northwestern Quebec. The highway begins at Route 111 in Macamic and ends at Témiscaming, a town bordering with Thorne, Ontario on the Ottawa River. It continues south as Highway 63 to North Bay, Ontario.