Quadrosilan Explained

Quadrosilan (brand name Cisobitan; former developmental code name KABI-1774) is a synthetic nonsteroidal estrogen that was developed in the 1970s and that is or has been used as an antigonadotropic agent in the treatment of prostate cancer.^{[1] [2] [3] [4]} It is an organosilicon compound, and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane.^[5] Quadrosilan has estrogenic activity equivalent to that of estradiol,^[6] and can produce feminization and gynecomastia as side effects in male patients.^{[7] [8]}

See also

• Paroxypropione
• Metallibure

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 629–.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 243–.
3. Alfthan O, Andersson L, Esposti PL, Fosså SD, Gammelgaard PA, Gjöres JE, Isacson S, Rasmussen F, Ruutu M, von Schreeb T, Setterberg G, Strandell P, Strindberg B . 6 . Cisobitan in treatment of prostatic cancer. A prospective controlled multicentre study . Scandinavian Journal of Urology and Nephrology . 17 . 1 . 37–43 . 1983 . 6346476 . 10.3109/00365598309179778 .
4. Chisholm GD . Treatment of advanced cancer of the prostate . Seminars in Surgical Oncology . 1 . 1 . 38–55 . 1985 . 3887539 . 10.1002/ssu.2980010106 .
5. Book: Apeloig Y . Yitzhak Apeloig. The Chemistry of Organic Silicon Compounds. 1989. John Wiley & Sons Canada, Limited. 978-0-471-91993-3. 1154.
6. Mills JS, Showell GA . Exploitation of silicon medicinal chemistry in drug discovery . Expert Opinion on Investigational Drugs . 13 . 9 . 1149–1157 . September 2004 . 15330746 . 10.1517/13543784.13.9.1149 . 26669175 .
7. Book: Strindberg B . Biochemistry of Silicon and Related Problems. Biochemical Effects of 2, 6-cis-Diphenylhexamethylcyclotetrasiloxane in Man. 1978. 515–520. 10.1007/978-1-4613-4018-8_23. 978-1-4613-4020-1.
8. Krarup T, Rasmussen F, Gammelgaard PA . Prostatic carcinoma treated with 2,6-cis-diphenylhexamethylcyclotetrasiloxane (Cisobitan) . Scandinavian Journal of Urology and Nephrology . 12 . 1 . 11–15 . 1978 . 345431 .