| Qasim I | |
| Succession: | Khan of the Tatar Astrakhan Khanate |
| Reign1: | 1466–1490 |
| Predecessor1: | Mahmud Astrakhani |
| Successor1: | Abdal-Karim Khan Astrakhani |
| Birth Date: | unknown |
| Death Date: | 1500 |
Qasim I Khan (died 1500) was a ruler of the Astrakhan Khanate in 1466–1500. He was crowned after the death of his father, Mäxmüd of Astrakhan.
Qasim gave refuge to Muhammad Shaybani and his brother Mahmud Sultan, allowing Shaybani to go on to reconquer most of the lands held by his grandfather, Abu'l-Khayr Khan.