| Official Name: | Qasem Khan |
| Native Name: | قاسم خان |
| Settlement Type: | village |
| Pushpin Map: | Iran |
| Mapsize: | 150px |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Name1: | North Khorasan |
| Subdivision Type2: | County |
| Subdivision Name2: | Esfarayen |
| Subdivision Type3: | Bakhsh |
| Subdivision Name3: | Central |
| Subdivision Type4: | Rural District |
| Subdivision Name4: | Azari |
| Population As Of: | 2006 |
| Population Total: | 308 |
| Population Density Km2: | auto |
| Timezone: | IRST |
| Utc Offset: | +3:30 |
| Timezone Dst: | IRDT |
| Utc Offset Dst: | +4:30 |
| Coordinates: | 36.8753°N 57.3622°W |
Qasem Khan (fa|قاسم خان, also Romanized as Qāsem Khān) is a village in Azari Rural District, in the Central District of Esfarayen County, North Khorasan Province, Iran. At the 2006 census, its population was 308, in 81 families.