PB-22 explained

PB-22 (QUPIC, SGT-21 or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013.[1] [2] PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs.

PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors.[3] PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing. One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.[4]

History

PB-22 was originally developed by New Zealand legal highs company Stargate International in 2012 as SGT-21, intended to be a structural hybrid of QMPSB and JWH-018.[5] However, no intellectual property protection was applied for and the compound quickly became subject to widespread grey-market sales outside the control of the inventors.

Detection

A forensic standard of PB-22 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[6]

Legal status

As of 9 May 2014, PB-22 is no longer legal in New Zealand.[7]

In January 2014, PB-22 was designated as a Schedule I controlled substance in the United States.[8] [9]

In Ohio, PB-22 is illegal.[10]

Florida also has banned PB-22.[11]

Since 13 December 2014 it is also illegal in Germany because of adding the substance to the BtMG Anlage II.

As of October 2015 PB-22 is a controlled substance in China.[12]

See also

Notes and References

  1. Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y . Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products . 10.1007/s11419-013-0182-9 . Forensic Toxicology . 2013 . 31 . 2 . 223–240. 1279637 .
  2. Lin M, Ellis B, Eubanks LM, Janda KD . Pharmacokinetic Approach to Combat the Synthetic Cannabinoid PB-22 . ACS Chemical Neuroscience . 12 . 14 . 2573–2579 . July 2021 . 34254505 . 10.1021/acschemneuro.1c00360 . 235808519 .
  3. Banister SD, Stuart J, Kevin RC, Edington A, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M . 6 . Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 . ACS Chemical Neuroscience . 6 . 8 . 1445–1458 . August 2015 . 25921407 . 10.1021/acschemneuro.5b00107 .
  4. Gugelmann H, Gerona R, Li C, Tsutaoka B, Olson KR, Lung D . 'Crazy Monkey' poisons man and dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid . Clinical Toxicology . 52 . 6 . 635–638 . July 2014 . 24905571 . 10.3109/15563650.2014.925562 . 207647659 .
  5. Brandt SD, Kavanagh PV, Westphal F, Dreiseitel W, Dowling G, Bowden MJ, Williamson JP . Synthetic cannabinoid receptor agonists: Analytical profiles and development of QMPSB, QMMSB, QMPCB, 2F-QMPSB, QMiPSB, and SGT-233 . Drug Testing and Analysis . 13 . 1 . 175–196 . January 2021 . 32880103 . 10.1002/dta.2913 . free .
  6. http://forendex.southernforensic.org/index.php/detail/index/1232 Forendex entry
  7. Web site: Legal highs pulled from shelves. New Zealand Herald . Jones N . 1 May 2014 . New Zealand Media and Entertainment . 18 August 2020 .
  8. Behonick G, Shanks KG, Firchau DJ, Mathur G, Lynch CF, Nashelsky M, Jaskierny DJ, Meroueh C . 6 . Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22 . Journal of Analytical Toxicology . 38 . 8 . 559–562 . October 2014 . 24876364 . 4334789 . 10.1093/jat/bku048 .
  9. Web site: PB-22 and 5F-PB-22 . Drug Enforcement Administration, Office of Diversion Control.
  10. News: Ohio bans two synthetic marijuana drugs sold as "herbal incense" . Jeremy . Pelzer . vanc . April 17, 2014 . cleveland.com.
  11. Web site: Statutes & Constitution :View Statutes : Online Sunshine . Leg.state.fl.us . 1997-05-06 . 2014-07-12.
  12. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . zh . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "PB-22".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.