Pyrroline-5-carboxylate reductase explained

pyrroline-5-carboxylate reductase
Ec Number:1.5.1.2
Cas Number:9029-17-8
Go Code:0004735
Width:270

In enzymology, a pyrroline-5-carboxylate reductase is an enzyme that catalyzes the chemical reaction

L-proline + NAD(P)+

\rightleftharpoons

1-pyrroline-5-carboxylate + NAD(P)H + H+

The 3 substrates of this enzyme are L-proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-5-carboxylate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 5-oxidoreductase. Other names in common use include proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and L-proline-NAD(P)+ 5-oxidoreductase. This enzyme participates in arginine and proline metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes,,,, and .

Human genes

References

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pyrroline-5-carboxylate reductase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.