Pyrrole–imidazole polyamides explained

Pyrrole–imidazole polyamides (PIPs) are a class of polyamides have the ability to bind to minor grooves found in the DNA helix.[1] [2] Scientists are experimenting with it as a drug-delivery mode that can switch genes on and off, as well as epigenetic modification in gene therapy.[3]

Notes and References

  1. Kawamoto . Yusuke . Bando . Toshikazu . Sugiyama . Hiroshi . Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications . Bioorganic & Medicinal Chemistry . May 2018 . 26 . 8 . 1393–1411 . 10.1016/j.bmc.2018.01.026. 29439914.
  2. Wu . Chunlei . Wang . Wei . Fang . Lijing . Su . Wu . Programmable pyrrole-imidazole polyamides: A potent tool for DNA targeting . Chinese Chemical Letters . July 2018 . 29 . 7 . 1105–1112 . 10.1016/j.cclet.2018.05.025. 102819448.
  3. Web site: Advancing gene therapies: PIP pip hurray!.

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