Pyroglutamylated RFamide peptide receptor explained

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.^[1]

Function

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.^[2]

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[3] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[4]

Further reading

• Lee DK, Nguyen T, Lynch KR, etal . Discovery and mapping of ten novel G protein-coupled receptor genes. . Gene . 275 . 1 . 83–91 . 2001 . 11574155 . 10.1016/S0378-1119(01)00651-5 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Jiang Y, Luo L, Gustafson EL, etal . Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. . J. Biol. Chem. . 278 . 30 . 27652–7 . 2003 . 12714592 . 10.1074/jbc.M302945200 . free .
• Fukusumi S, Yoshida H, Fujii R, etal . A new peptidic ligand and its receptor regulating adrenal function in rats. . J. Biol. Chem. . 278 . 47 . 46387–95 . 2004 . 12960173 . 10.1074/jbc.M305270200 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129.
• Takayasu S, Sakurai T, Iwasaki S, etal . A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 19 . 7438–43 . 2006 . 16648250 . 10.1073/pnas.0602371103 . 1464357. 2006PNAS..103.7438T . free .

External links

• Web site: Peptide P518 Receptor . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Notes and References

1. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF . Discovery and mapping of ten novel G protein-coupled receptor genes . Gene . 275 . 1 . 83–91 . September 2001 . 11574155 . 10.1016/S0378-1119(01)00651-5 .
2. Web site: Entrez Gene: GPR103 G protein-coupled receptor 103.
3. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL . Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 . J. Biol. Chem. . 278 . 30 . 27652–7 . July 2003 . 12714592 . 10.1074/jbc.M302945200 . free .
4. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M . A new peptidic ligand and its receptor regulating adrenal function in rats . J. Biol. Chem. . 278 . 47 . 46387–95 . November 2003 . 12960173 . 10.1074/jbc.M305270200 . free .