QRFP explained

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.^[1]

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[2] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[3]

External links

• Web site: Peptide P518 Receptor . IUPHAR/BPS Guide to PHARMACOLOGY .

Further reading

• Bruzzone F, Lectez B, Tollemer H, etal . Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. . J. Neurochem. . 99 . 2 . 616–27 . 2007 . 16899066 . 10.1111/j.1471-4159.2006.04090.x . 41427365 .
• Chartrel N, Bruzzone F, Dujardin C, etal . Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals . Ann. N. Y. Acad. Sci. . 1040 . 80–3 . 2006 . 1 . 15891009 . 10.1196/annals.1327.009 . 2005NYASA1040...80C . 21012765 .
• Thuau R, Guilhaudis L, Ségalas-Milazzo I, etal . Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. . Peptides . 26 . 5 . 779–89 . 2005 . 15808908 . 10.1016/j.peptides.2005.01.006 . 24088690 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chartrel N, Dujardin C, Anouar Y, etal . Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity . Proc. Natl. Acad. Sci. U.S.A. . 100 . 25 . 15247–52 . 2004 . 14657341 . 10.1073/pnas.2434676100 . 299975 . 2003PNAS..10015247C . free .
• Fukusumi S, Yoshida H, Fujii R, etal . A new peptidic ligand and its receptor regulating adrenal function in rats. . J. Biol. Chem. . 278 . 47 . 46387–95 . 2004 . 12960173 . 10.1074/jbc.M305270200 . free .
• Jiang Y, Luo L, Gustafson EL, etal . Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. . J. Biol. Chem. . 278 . 30 . 27652–7 . 2003 . 12714592 . 10.1074/jbc.M302945200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Web site: Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide.
2. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL . Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 . J. Biol. Chem. . 278 . 30 . 27652–7 . July 2003 . 12714592 . 10.1074/jbc.M302945200 . free .
3. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M . A new peptidic ligand and its receptor regulating adrenal function in rats . J. Biol. Chem. . 278 . 47 . 46387–95 . November 2003 . 12960173 . 10.1074/jbc.M305270200 . free .