Pyroglutamyl-histidyl-glycine explained

Pyroglutamyl-histidyl-glycine (pEHG) is an endogenous tripeptide that acts as a tissue-specific antimitotic and selectively inhibits the proliferation of colon epithelial cells.^[1] Early research indicated that pEHG had anorectic effects in mice and was possibly involved in the pathophysiology of anorexia nervosa.^[2] However, subsequent studies have found that pEHG lacks anorectic effects and does not alter food intake in mice.^{[3] [4]}

Notes and References

1. Reichelt . WH . Iversen . JG . Paulsen . JE . Elgjo . K . Reichelt . KL . Pyroglutamyl-histidyl-glycine, the endogenous colon mitosis inhibitor, regulates cyclic AMP level in non-tumorigenic colonic epithelial cells. . Anticancer Research . May 2004 . 24 . 3a . 1465–8 . 15274311.
2. Trygstad . Olav . Foss . Irene . Edminson . Paul D. . Johansen . John H. . Reichelt . Karl L. . Humoral Control of Appetite: A Urinary Anorexigenic Peptide. Chromatographic Patterns of Urinary Peptides in Anorexia Nervosa . European Journal of Endocrinology . 1 September 1978 . 89 . 1 . 196–208 . 10.1530/acta.0.0890196. 696172 .
3. Bauce . Lorenzo G. . Elliott . Crystal . Hughes . Rhiannon . Goren . H. Joseph . Synthesis and assay for activity of a proposed anorexogenic agent, L -pyroglutamyl- L -histidyl-glycine . Canadian Journal of Physiology and Pharmacology . 1 January 1981 . 59 . 1 . 88–90 . 10.1139/y81-015. 7214215 .
4. Nance . Dwight M. . Coy . David H. . Kastin . Abba J. . Experiments with a reported anorexigenic tripeptide: PyroGluHisGlyOH . Pharmacology Biochemistry and Behavior . December 1979 . 11 . 6 . 733–735 . 10.1016/0091-3057(79)90273-9. 538064 . 30289485 .