Pyrinuron Explained

Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide.[1] Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States.[2] If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes.[2] The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.[3]

Notes and References

  1. Vogel, R. P. . Poisoning with Vacor Rodenticide . Archives of Pathology and Laboratory Medicine . 1982 . 106 . 3 . 153 . 6895844 .
  2. Web site: Pyriminil . U.S. National Library of Medicine . 2013-11-04 . https://web.archive.org/web/20130704005423/http://hazmap.nlm.nih.gov/category-details?id=6918&table=copytblagents . 2013-07-04 . dead .
  3. Loreto. Andrea. Angeletti. Carlo. Gu. Weixi. Osborne. Andrew. Nieuwenhuis. Bart. Gilley. Jonathan. Arthur-Farraj. Peter. Merlini. Elisa. Amici. Adolfo. Luo. Zhenyao. Hartley-Tassell. Lauren. 2021-06-23. Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity. bioRxiv. en. 2020.09.18.304261. 10.1101/2020.09.18.304261. free.

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