Pyrazofurin Explained

Pyrazofurin (pyrazomycin) is a natural product found in Streptomyces candidus, which is a nucleoside analogue related to ribavirin. It has antibiotic, antiviral and anti-cancer properties but was not successful in human clinical trials due to severe side effects. Nevertheless, it continues to be the subject of ongoing research as a potential drug of last resort, or a template for improved synthetic derivatives.^{[1] [2] [3] [4] [5] [6] [7] [8]}

See also

• Acadesine
• EICAR (antiviral)
• Sangivamycin

Notes and References

1. Canonico PG, Jahrling PB, Pannier WL . Antiviral efficacy of pyrazofurin against selected RNA viruses . Antiviral Research . 2 . 6 . 331–7 . December 1982 . 6299188 . 10.1016/0166-3542(82)90002-x .
2. Buchanan JG . The C-nucleoside antibiotics . Fortschritte der Chemie Organischer Naturstoffe . 44 . 243–99 . 6360831 . 10.1007/978-3-7091-8714-2_4 . Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products . 1983 . 978-3-7091-8716-6 .
3. Hacksell U, Daves GD . The chemistry and biochemistry of C-nucleosides and C-arylglycosides . Progress in Medicinal Chemistry . 22 . 1–65 . 3915364 . 10.1016/s0079-6468(08)70228-5 . 1985 .
4. De Clercq E . Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives . Medicinal Research Reviews . 29 . 4 . 611–45 . July 2009 . 19260077 . 10.1002/med.20153 . 140127449 .
5. De Clercq E . Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential . Current Medicinal Chemistry . 22 . 34 . 3866–80 . 26112146 . 10.2174/0929867322666150625094705 . 2015 .
6. De Clercq E . C-Nucleosides To Be Revisited . Journal of Medicinal Chemistry . 59 . 6 . 2301–11 . March 2016 . 26513594 . 10.1021/acs.jmedchem.5b01157 .
7. De Clercq E . New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections . Chemistry: An Asian Journal . 14 . 22 . 3962–3968 . November 2019 . 31389664 . 10.1002/asia.201900841 . 7159701 .
8. Ren D, Wang SA, Ko Y, Geng Y, Ogasawara Y, Liu HW . Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin . Angewandte Chemie . 58 . 46 . 16512–16516 . November 2019 . 31518483 . 6911263 . 10.1002/anie.201910356 .