Pyeazolam Explained

Pyeazolam (SH-TRI-108) is a triazolobenzodiazepine derivative which has been sold online as a designer drug. It has been found to be relatively selective for the α₅ subtype of GABA_A receptors, in a similar manner to the related compound QH-ii-066,^[1] and is claimed to have an effects profile more similar to alcohol than typical benzodiazepines.

Several possible routes for synthesis have been determined.^[2]

See also

• GL-II-73
• Pyrazolam
• Pynazolam
• SH-053-R-CH3-2'F
• List of benzodiazepines

Notes and References

1. Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM . 6 . A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model . International Journal of Medicinal Chemistry . 2015 . 430248 . 2015 . 26682068 . 4657098 . 10.1155/2015/430248 . free .
2. https://www.benchchem.com/product/b1430148