Puzzle of the Space Pyramids is a fix-up science fiction novel by American writer Eando Binder. It tells the story of several successive space expeditions to Mars, Venus, Mercury and Jupiter. As each planet is found to harbor various (usually hostile) alien life, each expedition must survive both the elements and the attacks by the natives. The continuing thread through the expeditions is the discovery of an ancient pyramid on each planet they explore. These puzzling pyramids were apparently built by an unknown primeval civilization far older than and unrelated to the current inhabitants. When a final pyramid is found on Jupiter, its existence may point the way to their builder's secret.
The novel is a fix-up novel taken from stories published in the magazine Thrilling Wonder Stories.