| Puy-de-Serre | |
| Commune Status: | Commune |
| Arrondissement: | Fontenay-le-Comte |
| Canton: | Fontenay-le-Comte |
| Insee: | 85184 |
| Postal Code: | 85240 |
| Mayor: | Catherine Masson-Soulard[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Vendée Sèvre Autise |
| Coordinates: | 46.5631°N -0.6656°W |
| Elevation Min M: | 58 |
| Elevation Max M: | 124 |
| Area Km2: | 13.81 |
Puy-de-Serre (in French pronounced as /pɥi də sɛʁ/) is a commune in the Vendée department in the Pays de la Loire region in western France.