| Puskus Creek | |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Source1 Coordinates: | 34.3673°N -89.367°W |
| Mouth Coordinates: | 34.4545°N -89.2834°W |
Puskus Creek is a stream in the U.S. state of Mississippi.
Puskus is a name derived from the Choctaw language meaning "baby".[1] Variant names are "Puscoos Creek", "Puscus Creek", "Puscuss Creek", and "Puss Cuss Creek".