Pukateine Explained

Pukateine is an alkaloid found in the bark of the New Zealand tree Laurelia novae-zelandiae ("Pukatea"), as well as some South American plants.^[1] An extract from pukatea is used in traditional Māori herbal medicine as an analgesic.^{[2] [3]}

Bernard Cracroft Aston studied the physical and chemical characteristics of the compound, and presented a paper with his findings to the Royal Society of New Zealand on 11 May 1909.^[4]

Notes and References

1. Quiroz-Carreño S, Pastene-Navarrete E, Espinoza-Pinochet C, Muñoz-Núñez E, Devotto-Moreno L, Céspedes-Acuña CL, Alarcón-Enos J . Assessment of Insecticidal Activity of Benzylisoquinoline Alkaloids from Chilean Rhamnaceae Plants against Fruit-Fly Drosophila melanogaster and the Lepidopteran Crop Pest Cydia pomonella . Molecules . Basel, Switzerland . 25 . 21 . November 2020 . 5094 . 33153001 . 7663414 . 10.3390/molecules25215094 . free .
2. Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, Silveira R, Protais P, Russell G, Cassels BK, Dajas F . Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission . General Pharmacology . 32 . 3 . 373–9 . March 1999 . 10211594 . 10.1016/s0306-3623(98)00210-9 .
3. Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD . Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes . Planta Medica . 70 . 7 . 603–9 . July 2004 . 15254852 . 10.1055/s-2004-827181 . 260249660 .
4. Aston . Bernard Cracroft . 1909 . The Alkaloids of the Pukatea . Transactions of the Royal Society of New Zealand . 42 . October 20, 2015.