| Puka Mayu | |
| Name Etymology: | Quechua |
| Subdivision Type1: | Country |
| Subdivision Name1: | Bolivia |
| Subdivision Type3: | Region |
| Subdivision Name3: | Potosí Department |
| Source1 Location: | Cordillera de Lípez |
| Mouth: | Uyuni salt flat |
| Mouth Location: | Colcha "K" Municipality |
| Mouth Coordinates: | -20.4167°N -124°W |
| Mouth Elevation: | 3653m (11,985feet) |
Puka Mayu (Quechua puka red, mayu river,[1] "red river") is a Bolivian river in the Potosí Department, Nor Lípez Province, Colcha "K" Municipality.[2] [3] It originates in the Cordillera de Lípez[4] and empties into the Uyuni salt flat. The mouth lies west and south west of the town Uyuni and north east of the mouth of the Río Grande de Lípez.