| Puisieulx | |
| Commune Status: | Commune |
| Arrondissement: | Reims |
| Canton: | Reims-8 |
| Insee: | 51450 |
| Postal Code: | 51500 |
| Mayor: | André Secondé[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | CU Grand Reims |
| Coordinates: | 49.1939°N 4.1142°W |
| Elevation Min M: | 81 |
| Elevation Max M: | 148 |
| Area Km2: | 9.07 |
Puisieulx (in French pronounced as /pɥizjø/) is a commune in the Marne department in north-eastern France.
The village's vineyards are located in the Montagne de Reims subregion of Champagne, and are classified as Grand Cru (100%) in the Champagne vineyard classification.