| State: | PR |
| Type: | PR |
| Route: | 578 |
| Alternate Name: | Spanish; Castilian: Avenida José de Diego |
| Map Custom: | yes |
| Map Notes: | PR-578 highlighted in red |
| Length Km: | 0.8 |
| Direction A: | West |
| Terminus A: | in Bucaná–Sabanetas |
| Direction B: | East |
| Terminus B: | Calle Húcar in Vayas–Sabanetas |
| Municipalities: | Ponce |
| Previous Type: | Ter |
| Previous Route: | 577 |
| Next Type: | Urban |
| Next Route: | 585 |
Puerto Rico Highway 578 (PR-578) is tertiary[1] state highway in Ponce, Puerto Rico. The road runs from east to west, parallel to PR-1, and it forms the boundary between the northern end of barrio Bucaná and the southern end of barrio Sabanetas. The road is located entirely within the municipality of Ponce.[2]