| State: | PR |
| Type: | PR |
| Route: | 501 |
| Maint: | Puerto Rico DTPW |
| Map: | Mapa de la carretera PR-501 en Ponce, Puerto Rico (M501).svg |
| Length Km: | 10.3 |
| Direction A: | South |
| Direction B: | North |
| Section1: | Southern segment |
| Terminus A1: | in Magueyes |
| Junction1: | in Marueño |
| Terminus B1: | Sector La Jagua in Marueño |
| Section2: | Northern segment |
| Terminus A2: | Sector Las Lomas in Marueño |
| Terminus B2: | in Guaraguao |
| Municipalities: | Ponce |
| Previous Type: | Urban |
| Previous Route: | 500 |
| Next Type: | Ter |
| Next Route: | 502 |
Puerto Rico Highway 501 (PR-501) is a tertiary[1] state highway in Ponce, Puerto Rico. The road runs north to south, and mostly alongside Rio Pastillo in barrio Marueño. It southern terminus is at PR-123, just off Calle 18 of Urbanización Las Delicias in barrio Magueyes, and its northern end is also at PR-123 but in barrio Guaraguao.