| State: | PR |
| Type: | PR |
| Route: | 161 |
| Alternate Name: | Spanish; Castilian: Desvío Norte Luis Muñoz Marín |
| Length Km: | 2.4 |
| Direction A: | West |
| Terminus A: | in Boca Velázquez |
| Junction: | in Boca Velázquez–Santa Isabel barrio-pueblo |
| Direction B: | East |
| Terminus B: | in Felicia 1 |
| Municipalities: | Santa Isabel |
| Previous Type: | Ter |
| Previous Route: | 160 |
| Next Type: | Sec |
| Next Route: | 162 |
Puerto Rico Highway 161 (PR-161) is an east–west bypass located north of downtown Santa Isabel, Puerto Rico.[1] This road serves as an alternate route to the PR-1 and is known as Desvío Norte Luis Muñoz Marín.[2]