| State: | PR |
| Type: | PR |
| Route: | 122 |
| Length Km: | 6.7 |
| Direction A: | South |
| Direction B: | North |
| Section1: | Southern segment |
| Terminus A1: | in Lajas |
| Terminus B1: | in Lajas–Ancones |
| Section2: | Northern segment |
| Terminus A2: | in Retiro |
| Junction2: | |
| Terminus B2: | in Caín Alto |
| Municipalities: | Lajas, San Germán |
| Previous Type: | Sec |
| Previous Route: | 121 |
| Next Type: | PR |
| Next Route: | 123 |
Puerto Rico Highway 122 (PR-122) is a north–south road between the municipalities of San Germán and Lajas, Puerto Rico. In San Germán, it begins at PR-2 and ends at PR-166,[1] and in Lajas, it extends from PR-116 to PR-321.[2] When completed, it will be extend from PR-116 at its southern terminus to PR-2 interchange in the northern end.
PR-122 is mostly an avenue connecting downtown San Germán with PR-2. After intersecting with PR-166, the avenue ends and the highway becomes a narrow, rural road until its end.[3] On June 22, 2023, the Governor of Puerto Rico announced that a budget has been assigned to build the last segment of PR-122 between San Germán and Lajas at an estimated cost of $53.3 million. This new route will facilitate access to Lajas, creating an alternative route to PR-101.[2]