| Puerto Leguizamo | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Name: |  Colombia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Putumayo Department |
| Area Total Km2: | 10907 |
| Area Urban Km2: | 2.13 |
| Population As Of: | 2018 census |
| Population Footnotes: | [1] |
| Population Total: | 28468 |
| Population Density Km2: | auto |
| Population Urban: | 12755 |
| Population Density Urban Km2: | auto |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
| Elevation M: | 177 |
Puerto Leguízamo[2] (pronounced as /es/) is a town and municipality located in the Putumayo Department, a southern border region of the Republic of Colombia. It is on the north bank of the Putumayo River.
Its Catedral Nuestra Señora del Carmen, dedicated to Our Lady of Mount Carmel, is the cathedral episcopal see of the Latin Catholic missionary pre-diocesan Apostolic Vicariate of Puerto Leguízamo-Solano.
Puerto Leguízamo is served by Caucayá Airport.
Located just a few kilometres south of the equator, Puerto Leguízamo has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round.