| Official Name: | Psimolofou |
| Native Name: | Ψιμολόφου |
| Pushpin Map: | Cyprus |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Cyprus |
| Subdivision Type: | Country |
| Subdivision Name: |  Cyprus |
| Subdivision Type1: | District |
| Subdivision Type2: | Municipality |
| Unit Pref: | Imperial |
| Population As Of: | 2011 |
| Population Footnotes: | [1] |
| Population Total: | 1,686 |
| Timezone: | EET |
| Utc Offset: | +2 |
| Timezone Dst: | EEST |
| Utc Offset Dst: | +3 |
| Coordinates: | 35.0606°N 33.26°W |
Psimolofou or Psimolophou (Ψιμολόφου) is a village located about 16 km from Nicosia District Capital of Cyprus, en route to the historic Machairas Monastery.
Psimolofou rests at a height of 340 meters above sea level and it is surrounded by a number of perfectly flat hills and it is only 500 meters away from Padiaos river.
Psimolofou was established as a small village since the 12th century AD. The Old village in the center has narrow streets and very old houses made of soil and hay blocks called plynths ( Πλύνθοι)
Psimolofou (Ψιμολόφου) derived its name from a small hill nearby which resembles a bread (ψωμί). However, most probably the name has been derived from the nearby hill - tall hill (ψηλός λόφος).
According to Jean Richard in a paper written in Melanges d'Archeologie et d'Histoire, Psimolophou was one of Cyprus's main centres for tanning, the craft practiced by Jewish tanners from the 14th century until the second half of the 20th century.
Psimolofou has approximately 2000 residents and it has been growing steadily since the 19th century where records were kept. Up until the 1970s, most of the inhabitants were involved with agriculture - growing fruits and vegetables. Today, very few inhabitants are still farmers. Most of the residents now hold jobs or have businesses in Nicosia.
Psimolofou is a fast expanding residential area very near to the city but with cooler climate especially in the summer with only detached and some semi detached houses. Psimolofou has public elementary and primary schools.
The church of Psimolofou is dedicated to Panayia Katholoki which was built in the 19th century over the ruins of an older church that was destroyed by fire. It is decorated with wall paintings. Two of them from the earlier building and the rest in the very recent years. There are two other churches, a ruined one from the medieval ages and a modern one built in the late 20th century.
There is a bank with an ATM, a well sized supermarket, a hardware store, a car tyres shop, 3 traditional Cyprus coffee shops and a 24-hour 365 days convenience store.
Near Psimolofou at 35.0531°N 33.2962°W, there is a mediumwave broadcasting station transmitting on 963 kHz the 1st programme and on 603 kHz the third programme with 100 Kilowatt. It uses a 193 metres tall guyed mast radiator - the tallest structure in Cyprus.