Pseudoprotease Explained

Pseudoproteases are catalytically-deficient pseudoenzyme variants of proteases that are represented across the kingdoms of life.^{[1] [2]}

Examples

Superfamilies containing pseudoenzymes with inactive triads ^[3] !Superfamily!Families containing pseudoenzymes!Examples

CA clan	C1, C2, C19	Calpamodulin
CD clan	C14	CFLAR
SC clan	S9, S33	Neuroligin
SK clan	S14	ClpR
SR clan	S60	Serotransferrin domain 2
ST clan	S54	RHBDF1
PA clan	S1	Azurocidin 1
PB clan	T1	PSMB3

See also

• Protease
• Pseudoenzyme
• Catalytic triad

Notes and References

1. Fischer. Katja. Reynolds. Simone L.. 2015-05-15. Pseudoproteases: mechanisms and function. Biochemical Journal. en. 468. 1. 17–24. 10.1042/BJ20141506. 1470-8728. 25940733.
2. Todd AE, Orengo CA, Thornton JM. October 2002. Sequence and structural differences between enzyme and nonenzyme homologs. Structure. 10. 10. 1435–51. 10.1016/s0969-2126(02)00861-4. 12377129. free.
3. Fischer. Katja. Reynolds. Simone L.. 2015-05-15. Pseudoproteases: mechanisms and function. Biochemical Journal. en. 468. 1. 17–24. 10.1042/BJ20141506. 1470-8728. 25940733.