Pseudolysin Explained

Pseudolysin
Ec Number:	3.4.24.26
Cas Number:	171715-23-4

Pseudolysin (Pseudomonas elastase, Pseudomonas aeruginosa neutral metalloproteinase) is an enzyme.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects

This enzyme belongs to the peptidase family M4 (thermolysin family).

Notes and References

1. Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase . Morihara K, Tsuzuki H . Agric. Biol. Chem. . 1975 . 39 . 1123–1128 . 10.1271/bbb1961.39.1123. free .
2. Nishino N, Powers JC . Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand . The Journal of Biological Chemistry . 255 . 8 . 3482–6 . April 1980 . 6767718 .
3. Dreyfus LA, Iglewski BH . Purification and characterization of an extracellular protease of Legionella pneumophila . Infection and Immunity . 51 . 3 . 736–43 . March 1986 . 3512431 . 260959 .
4. Bever RA, Iglewski BH . Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene . Journal of Bacteriology . 170 . 9 . 4309–14 . September 1988 . 2842313 . 211443 .
5. Black WJ, Quinn FD, Tompkins LS . Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase . Journal of Bacteriology . 172 . 5 . 2608–13 . May 1990 . 2110146 .