Pseudohypericin Explained

Pseudohypericin is an aromatic polycyclic dione that is very closely related to hypericin. It is found most commonly in the St. John's wort family of plants, namely in Hypericum perforatum.[1] In preliminary studies in animal models, pseudohypericin has shown antiviral effects.[2] [3] It may also contribute to the potential antidepressant effect of Hypericum perforatum extracts.[4]

Notes and References

  1. 10.1016/S0305-1978(00)00032-6 . Hypericin and pseudohypericin in some Hypericum species . Biochemical Systematics and Ecology . 29 . 2 . 171–178 . 2001 . Kitanov . Gerassim M. . 11106845 .
  2. 281723 . 10.1073/pnas.85.14.5230. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin. Proceedings of the National Academy of Sciences. 85. 14. 5230–5234. 1988. Meruelo. D.. Lavie. G.. Lavie. D.. 2839837. 1988PNAS...85.5230M. free.
  3. 10.1016/0166-3542(91)90028-P . Antiviral activities of hypericin . Antiviral Research . 15 . 2 . 101–112 . 1991 . Hudson . J.B. . Lopez-Bazzocchi . I. . Towers . G.H.N. . 1650164 .
  4. 10.1055/s-2006-957437 . Solubilized Hypericin and Pseudohypericin from Hypericum perforatum Exert Antidepressant Activity in the Forced Swimming Test3 . Planta Medica . 64 . 4 . 291–294 . 1998 . Butterweck . Veronika . Petereit . Frank . Winterhoff . Hilke . Nahrstedt . Adolf . 9619107 .

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